AustralieFrV1, Main, Exploration, bibRecord, 009691

Change in salt intake affects blood pressure of chimpanzees : Implications for human populations

Identifieur interne : 009691 ( Main/Exploration ); précédent : 009690; suivant : 009692

Change in salt intake affects blood pressure of chimpanzees : Implications for human populations

Auteurs : Paul Elliott [Royaume-Uni] ; Lesley L. Walker [Australie] ; Mark P. Little [Royaume-Uni] ; John R. Blair-West [Australie, États-Unis] ; Robert E. Shade [États-Unis] ; D. Rick Lee [États-Unis] ; Pierre Rouquet [Gabon] ; Eric Leroy [Gabon] ; Xavier Jeunemaitre [France] ; Raymond Ardaillou [France] ; Francoise Paillard [France] ; Pierre Meneton [France] ; Derek A. Denton [États-Unis, Australie]

Source :

Circulation : (New York, N.Y.) [ 0009-7322 ] ; 2007.

RBID : Pascal:07-0475335

Descripteurs français

Pascal (Inist)
- Appareil circulatoire pathologie, Hypertension artérielle, Pression artérielle, Pression sanguine, Homme, Sodium.
Wicri :
- topic : Homme, Sodium.

English descriptors

KwdEn :
- Arterial pressure, Blood pressure, Cardiovascular disease, Human, Hypertension, Sodium.

Abstract

Background-Addition of up to 15.0 g/d salt to the diet of chimpanzees caused large rises in blood pressure, which reversed when the added salt was removed. Effects of more modest alterations to sodium intakes in chimpanzees, akin to current efforts to lower sodium intakes in the human population, are unknown. Methods and Results-Sodium intakes were altered among 17 chimpanzees in Franceville, Gabon, and 110 chimpanzees in Bastrop, Tex. In Gabon, chimpanzees had a biscuit diet of constant nutrient composition except that the sodium content was changed episodically over 3 years from 75 to 35 to 120 mmol/d. In Bastrop, animals were divided into 2 groups; 1 group continued on the standard diet of 250 mmol/d sodium for 2 years, and sodium intake was halved for the other group. Lower sodium intake was associated with lower systolic, diastolic, and mean arterial blood pressures in Gabon (2-tailed P<0.001, unadjusted and adjusted for age, sex, and baseline weight) and Bastrop (P<0.01, unadjusted; P=0.08 to 0.10, adjusted), with no threshold down to 35 mmol/d sodium. For systolic pressure, estimates were -12.7 mm Hg (95% confidence interval, -16.9 to -8.5, adjusted) per 100 mmol/d lower sodium in Gabon and - 10.9 mm Hg (95% confidence interval, -18.9 to -2.9, unadjusted) and -5.7 mm Hg (95% confidence interval, - 12.2 to 0.7, adjusted) for sodium intake lower by 122 mmol/d in Bastrop. Baseline systolic pressures higher by 10 mm Hg were associated with larger falls in systolic pressure by 4.3/2.9 mm Hg in Gabon/Bastrop per 100 mmol/d lower sodium. Conclusions-These findings from an essentially single-variable experiment in the species closest to Homo sapiens with high intakes of calcium and potassium support intensified public health efforts to lower sodium intake in the human population.

Affiliations:

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Le document en format XML

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<author><name sortKey="Meneton, Pierre" sort="Meneton, Pierre" uniqKey="Meneton P" first="Pierre" last="Meneton">Pierre Meneton</name>
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<author><name sortKey="Denton, Derek A" sort="Denton, Derek A" uniqKey="Denton D" first="Derek A." last="Denton">Derek A. Denton</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Physiology and Medicine, Southwest Foundation for Biomedical Research</s1>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Change in salt intake affects blood pressure of chimpanzees : Implications for human populations</title>
<author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology and Public Health, Imperial College London</s1>
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<author><name sortKey="Walker, Lesley L" sort="Walker, Lesley L" uniqKey="Walker L" first="Lesley L." last="Walker">Lesley L. Walker</name>
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<author><name sortKey="Blair West, John R" sort="Blair West, John R" uniqKey="Blair West J" first="John R." last="Blair-West">John R. Blair-West</name>
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<author><name sortKey="Shade, Robert E" sort="Shade, Robert E" uniqKey="Shade R" first="Robert E." last="Shade">Robert E. Shade</name>
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<author><name sortKey="Rick Lee, D" sort="Rick Lee, D" uniqKey="Rick Lee D" first="D." last="Rick Lee">D. Rick Lee</name>
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<author><name sortKey="Rouquet, Pierre" sort="Rouquet, Pierre" uniqKey="Rouquet P" first="Pierre" last="Rouquet">Pierre Rouquet</name>
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<author><name sortKey="Leroy, Eric" sort="Leroy, Eric" uniqKey="Leroy E" first="Eric" last="Leroy">Eric Leroy</name>
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<author><name sortKey="Jeunemaitre, Xavier" sort="Jeunemaitre, Xavier" uniqKey="Jeunemaitre X" first="Xavier" last="Jeunemaitre">Xavier Jeunemaitre</name>
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<author><name sortKey="Ardaillou, Raymond" sort="Ardaillou, Raymond" uniqKey="Ardaillou R" first="Raymond" last="Ardaillou">Raymond Ardaillou</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Hôpital Tenon</s1>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
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<author><name sortKey="Paillard, Francoise" sort="Paillard, Francoise" uniqKey="Paillard F" first="Francoise" last="Paillard">Francoise Paillard</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Hôpital Tenon</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meneton, Pierre" sort="Meneton, Pierre" uniqKey="Meneton P" first="Pierre" last="Meneton">Pierre Meneton</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>INSERM U872, Département de Santé Publique et d'Informatique Médicale, Faculté de Médecine René Descartes</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Denton, Derek A" sort="Denton, Derek A" uniqKey="Denton D" first="Derek A." last="Denton">Derek A. Denton</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Physiology and Medicine, Southwest Foundation for Biomedical Research</s1>
<s2>San Antonio, Tex</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>San Antonio, Tex</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Baker Medical Research Institute</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Baker Medical Research Institute</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Circulation : (New York, N.Y.)</title>
<title level="j" type="abbreviated">Circulation : (N. Y. N.Y.)</title>
<idno type="ISSN">0009-7322</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Circulation : (New York, N.Y.)</title>
<title level="j" type="abbreviated">Circulation : (N. Y. N.Y.)</title>
<idno type="ISSN">0009-7322</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arterial pressure</term>
<term>Blood pressure</term>
<term>Cardiovascular disease</term>
<term>Human</term>
<term>Hypertension</term>
<term>Sodium</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Appareil circulatoire pathologie</term>
<term>Hypertension artérielle</term>
<term>Pression artérielle</term>
<term>Pression sanguine</term>
<term>Homme</term>
<term>Sodium</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
<term>Sodium</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background-Addition of up to 15.0 g/d salt to the diet of chimpanzees caused large rises in blood pressure, which reversed when the added salt was removed. Effects of more modest alterations to sodium intakes in chimpanzees, akin to current efforts to lower sodium intakes in the human population, are unknown. Methods and Results-Sodium intakes were altered among 17 chimpanzees in Franceville, Gabon, and 110 chimpanzees in Bastrop, Tex. In Gabon, chimpanzees had a biscuit diet of constant nutrient composition except that the sodium content was changed episodically over 3 years from 75 to 35 to 120 mmol/d. In Bastrop, animals were divided into 2 groups; 1 group continued on the standard diet of 250 mmol/d sodium for 2 years, and sodium intake was halved for the other group. Lower sodium intake was associated with lower systolic, diastolic, and mean arterial blood pressures in Gabon (2-tailed P<0.001, unadjusted and adjusted for age, sex, and baseline weight) and Bastrop (P<0.01, unadjusted; P=0.08 to 0.10, adjusted), with no threshold down to 35 mmol/d sodium. For systolic pressure, estimates were -12.7 mm Hg (95% confidence interval, -16.9 to -8.5, adjusted) per 100 mmol/d lower sodium in Gabon and - 10.9 mm Hg (95% confidence interval, -18.9 to -2.9, unadjusted) and -5.7 mm Hg (95% confidence interval, - 12.2 to 0.7, adjusted) for sodium intake lower by 122 mmol/d in Bastrop. Baseline systolic pressures higher by 10 mm Hg were associated with larger falls in systolic pressure by 4.3/2.9 mm Hg in Gabon/Bastrop per 100 mmol/d lower sodium. Conclusions-These findings from an essentially single-variable experiment in the species closest to Homo sapiens with high intakes of calcium and potassium support intensified public health efforts to lower sodium intake in the human population.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Gabon</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Londres</li>
<li>Melbourne</li>
<li>Paris</li>
</settlement>
<orgName><li>Université Paris-Descartes</li>
<li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name>
</region>
<name sortKey="Little, Mark P" sort="Little, Mark P" uniqKey="Little M" first="Mark P." last="Little">Mark P. Little</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Walker, Lesley L" sort="Walker, Lesley L" uniqKey="Walker L" first="Lesley L." last="Walker">Lesley L. Walker</name>
</region>
<name sortKey="Blair West, John R" sort="Blair West, John R" uniqKey="Blair West J" first="John R." last="Blair-West">John R. Blair-West</name>
<name sortKey="Denton, Derek A" sort="Denton, Derek A" uniqKey="Denton D" first="Derek A." last="Denton">Derek A. Denton</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Blair West, John R" sort="Blair West, John R" uniqKey="Blair West J" first="John R." last="Blair-West">John R. Blair-West</name>
</noRegion>
<name sortKey="Denton, Derek A" sort="Denton, Derek A" uniqKey="Denton D" first="Derek A." last="Denton">Derek A. Denton</name>
<name sortKey="Rick Lee, D" sort="Rick Lee, D" uniqKey="Rick Lee D" first="D." last="Rick Lee">D. Rick Lee</name>
<name sortKey="Rick Lee, D" sort="Rick Lee, D" uniqKey="Rick Lee D" first="D." last="Rick Lee">D. Rick Lee</name>
<name sortKey="Shade, Robert E" sort="Shade, Robert E" uniqKey="Shade R" first="Robert E." last="Shade">Robert E. Shade</name>
</country>
<country name="Gabon"><noRegion><name sortKey="Rouquet, Pierre" sort="Rouquet, Pierre" uniqKey="Rouquet P" first="Pierre" last="Rouquet">Pierre Rouquet</name>
</noRegion>
<name sortKey="Leroy, Eric" sort="Leroy, Eric" uniqKey="Leroy E" first="Eric" last="Leroy">Eric Leroy</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Jeunemaitre, Xavier" sort="Jeunemaitre, Xavier" uniqKey="Jeunemaitre X" first="Xavier" last="Jeunemaitre">Xavier Jeunemaitre</name>
</region>
<name sortKey="Ardaillou, Raymond" sort="Ardaillou, Raymond" uniqKey="Ardaillou R" first="Raymond" last="Ardaillou">Raymond Ardaillou</name>
<name sortKey="Jeunemaitre, Xavier" sort="Jeunemaitre, Xavier" uniqKey="Jeunemaitre X" first="Xavier" last="Jeunemaitre">Xavier Jeunemaitre</name>
<name sortKey="Meneton, Pierre" sort="Meneton, Pierre" uniqKey="Meneton P" first="Pierre" last="Meneton">Pierre Meneton</name>
<name sortKey="Paillard, Francoise" sort="Paillard, Francoise" uniqKey="Paillard F" first="Francoise" last="Paillard">Francoise Paillard</name>
</country>
</tree>
</affiliations>
</record>

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Change in salt intake affects blood pressure of chimpanzees : Implications for human populations

Change in salt intake affects blood pressure of chimpanzees : Implications for human populations

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